| Team | Player | Pos. | Rushes | Yds. | Yds./Rush | 1st Rushes | 2nd Rushes | Yds./1st Down | Yds./2nd Down | 1st Gained | TD | Total EPA | EPA/Rush | EPA/1st Down | EPA/2nd Down |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BC | Nathan Rourke | QB | 21 | 163 | 7.8 | 8 | 10 | 8 | 9.4 | 13 | 2 | 15.29 | 0.73 | 0.50 | 1.10 |
| EDM | Tre Ford | QB | 14 | 138 | 9.9 | 4 | 10 | 5.8 | 11.5 | 7 | 1 | 11.98 | 0.86 | 0.09 | 1.16 |
| CGY | Quincy Vaughn | QB | 12 | 26 | 2.2 | 0 | 7 | 2.6 | 12 | 0 | 10.91 | 0.91 | 0.55 | ||
| SSK | Tommy Stevens | QB | 20 | 79 | 4.0 | 4 | 11 | 4.8 | 4.5 | 14 | 2 | 9.64 | 0.48 | 0.11 | 0.49 |
| CGY | Dedrick Mills | RB | 77 | 396 | 5.1 | 57 | 20 | 5.0 | 5.6 | 17 | 5 | 7.86 | 0.10 | 0.01 | 0.37 |
| OTT | Daniel Adeboboye | RB | 22 | 160 | 7.3 | 15 | 6 | 5.7 | 11.7 | 5 | 0 | 5.02 | 0.23 | -0.04 | 0.68 |
| SSK | A.J. Ouellette | RB | 62 | 356 | 5.7 | 55 | 7 | 6.0 | 4 | 8 | 3 | 3.67 | 0.06 | 0.06 | 0.05 |
| HAM | Ante Milanovic-Litre | RB | 16 | 52 | 3.3 | 3 | 7 | 5.7 | 2.4 | 12 | 1 | 3.37 | 0.21 | 0.23 | 0.09 |
| OTT | Dustin Crum | QB | 25 | 127 | 5.1 | 9 | 10 | 10.8 | 2.4 | 11 | 3 | 2.98 | 0.12 | 0.59 | -0.49 |
| TOR | Nick Arbuckle | QB | 12 | 57 | 4.8 | 3 | 8 | 4.3 | 5.3 | 5 | 0 | 2.80 | 0.23 | -0.08 | 0.24 |
| MTL | Travis Theis | RB | 23 | 129 | 5.6 | 16 | 7 | 3.8 | 9.7 | 8 | 0 | 2.47 | 0.11 | -0.07 | 0.51 |
| SSK | Thomas Bertrand-Hudon | RB | 19 | 96 | 5.1 | 13 | 6 | 4.5 | 6.2 | 5 | 1 | 2.33 | 0.12 | -0.05 | 0.50 |
| OTT | William Stanback | RB | 37 | 193 | 5.2 | 30 | 7 | 6 | 1.9 | 6 | 2 | 2.33 | 0.06 | 0.08 | -0.01 |
| WPG | Brady Oliveira | RB | 15 | 110 | 7.3 | 10 | 5 | 8.5 | 5 | 6 | 0 | 1.47 | 0.10 | 0.11 | 0.08 |
| WPG | Quinton Cooley | RB | 11 | 62 | 5.6 | 9 | 2 | 5.3 | 7 | 4 | 0 | 1.16 | 0.11 | 0.00 | 0.59 |
| BC | James Butler | RB | 85 | 468 | 5.5 | 59 | 25 | 5.7 | 5.2 | 21 | 3 | 0.19 | 0.00 | -0.15 | 0.29 |
| WPG | Matthew Peterson | RB | 48 | 245 | 5.1 | 36 | 10 | 5.5 | 4.3 | 11 | 1 | -1.12 | -0.02 | -0.01 | 0.02 |
| MTL | Sean Thomas-Erlington | RB | 47 | 246 | 5.2 | 36 | 11 | 5.1 | 5.5 | 11 | 1 | -1.68 | -0.04 | -0.09 | 0.13 |
| EDM | Javon Leake | RB | 18 | 90 | 5 | 14 | 4 | 4.1 | 8 | 5 | 0 | -1.84 | -0.10 | -0.22 | 0.32 |
| EDM | Justin Rankin | RB | 29 | 134 | 4.6 | 25 | 3 | 4.7 | 3.3 | 8 | 0 | -2.15 | -0.07 | -0.14 | 0.26 |
| HAM | Greg Bell | RB | 24 | 108 | 4.5 | 19 | 4 | 4.6 | 5.3 | 3 | 1 | -3.00 | -0.12 | -0.07 | 0.17 |
| HAM | Johnny Augustine | RB | 31 | 116 | 3.7 | 24 | 7 | 4.3 | 2 | 5 | 0 | -3.72 | -0.12 | -0.16 | 0.03 |
| TOR | Miyan Williams | RB | 21 | 102 | 4.9 | 17 | 3 | 3.6 | 9.3 | 6 | 0 | -4.09 | -0.19 | -0.20 | -0.42 |
| TOR | Kevin Brown | RB | 18 | 37 | 2.1 | 9 | 7 | 3.9 | -0.1 | 4 | 1 | -7.74 | -0.43 | -0.06 | -0.53 |