| Team | Player | Pos. | Rushes | Yds. | Yds./Rush | 1st Rushes | 2nd Rushes | Yds./1st Down | Yds./2nd Down | 1st Gained | TD | Total EPA | EPA/Rush | EPA/1st Down | EPA/2nd Down |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CGY | Tiyon Evans | RB | 13 | 63 | 4.8 | 8 | 4 | 4.9 | 4.5 | 3 | 1 | 4.12 | 0.32 | -0.11 | 1.05 |
| HAM | Treshaun Ward | RB | 17 | 136 | 8 | 14 | 3 | 6.5 | 15 | 2 | 1 | 2.93 | 0.17 | 0.04 | 0.81 |
| WPG | Quinton Cooley | RB | 13 | 92 | 7.1 | 7 | 6 | 7.4 | 6.7 | 5 | 0 | 1.67 | 0.13 | 0.05 | 0.22 |
| TOR | Jyran Mitchell | RB | 11 | 118 | 10.7 | 8 | 2 | 13.3 | 6 | 2 | 1 | 0.83 | 0.08 | 0.76 | -0.42 |
| EDM | DeWayne McBride | RB | 11 | 47 | 4.3 | 7 | 3 | 4.6 | 4 | 3 | 1 | 0.01 | 0.00 | -0.32 | 0.50 |
| BC | Jordan Terrell | RB | 11 | 49 | 4.5 | 8 | 3 | 4.1 | 5.3 | 3 | 0 | -0.06 | -0.01 | -0.30 | 0.78 |
| SSK | Mario Anderson | RB | 14 | 37 | 2.6 | 10 | 4 | 2.5 | 3 | 2 | 2 | -0.12 | -0.01 | 0.23 | -0.60 |
| CGY | Eno Benjamin | RB | 12 | 44 | 3.7 | 8 | 3 | 4.9 | 1 | 2 | 0 | -1.29 | -0.11 | -0.11 | -0.56 |
| BC | Zander Horvath | RB | 12 | 48 | 4 | 8 | 3 | 4.9 | 3.7 | 4 | 0 | -2.53 | -0.21 | -0.21 | 0.43 |
| WPG | Matthew Peterson | RB | 11 | 34 | 3.1 | 9 | 2 | 2.7 | 5 | 1 | 0 | -3.41 | -0.31 | -0.38 | 0.00 |
| EDM | Artavis Pierce | RB | 10 | 13 | 1.3 | 8 | 1 | 1.3 | 3 | 2 | 0 | -6.59 | -0.66 | -0.48 | 0.52 |